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KMID : 1000620030010020020
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International Journal of Vascular Biomedical Engineering
2003 Volume.1 No. 2 p.20 ~ p.29
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Hemodynamics of a Connecting conduit Between the Left Ventricle and the Left Decending Coronary Artery
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Shim Eun-Bo
Sah Jong-Yub
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Abstract
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A new treatment for coronary artery occlusive disease is being developed in which a shunt or conduit is placed directly connecting the left ventricle with the diseased artery at a point distal to the obstruction. To aid in assessing and optimizing its benefit, a computational model of the cardiovascular system was developed and used to explore various design conditions. Simulation results indicate that in complete LAD occlusion, flow can be returned to approximately 65% of normal if the conduit resistance is equal for forward and reverse flow, increasing to 80% in the limit in which backflow resistance is infinite. Increases in flow rate produced by asymmetric flow resistance are considerably enhanced in the case of a partial LAD obstruction since the primary effect of resistance asymmetry is to prevent leakage back into the ventricle("steal") during diastole. Increased arterial compliance has little effect on net flow with a symmetric shunt, but leads to considerable augmentation when the resistance is asymmetric. These results suggest that an LV-LAD conduit will be beneficial when stenosis resistance(Rst) > 27 PRU if resistance is symmetric.
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KEYWORD
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Coronary Artery, Occlusion, LV-LAD Bybass, Lumped Parameter Model
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